Cell Metabolism | 谷氨酰胺酶抑制损害 STK11-/Lkb1 缺陷型肺癌中 CD8 T 细胞的活化

Best等人研究了 KRAS 突变肺腺癌的代谢，发现 STK11/Lkb1 共突变 (KL) 导致谷氨酸和谷氨酰胺酶增加。 在 KL 模型中，谷氨酰胺酶抑制 (CB-839) 联合免疫疗法 (anti-PD1) 在体内无效，导致 CD8 T 细胞的克隆扩增和细胞

Cell Host & Microbe | 宿主细胞将营养生态位细化为肠道微生物离散的生物地理微生境

Liou等人发现致病性沙门氏菌和共生大肠杆菌在肠道腔内不同空间微生境中获得硝酸盐，这些空间微生境由不同的宿主细胞类型产生。大肠杆菌入侵沙门氏菌占据的空间微生境的能力有助于抗定植。

Cell Reports | 生信分析 | 全基因组识别和分析人类癌症的预后特征

Smith 和 Sheltzer 确定了与 32 种癌症类型的结果相关的基因组改变。他们确定了数千个预后生物标志物，并揭示了基因拷贝数改变与患者死亡之间的显著关联。 可以挖掘这一综合资源来探寻最有可能揭示患者疾病进展的生物标志物。

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